Extinct human relatives left a genetic gift that helped people thrive in the Americas

Scientists have discovered that a gene called MUC19, inherited from Denisovans through ancient interbreeding, may have played a vital role in helping Indigenous ancestors adapt as they migrated into the Americas. Found at unusually high frequencies in both modern and ancient populations, the gene likely provided immune advantages against new pathogens. This research highlights how archaic DNA, passed through both Denisovans and Neanderthals, enriched human genetic diversity in ways that still shape us today.